Does intranasal dexmedetomidine provide adequate plasma concentrations for sedation in children: a pharmacokinetic study.
Intranasal dexmedetomidine (DMT) has been used for sedation in children around the world (including in our institution) for some years now – interestingly in the absence of any pharmacokinetic data. This paper from Cincinnati Children’s Hospital Medical Centre studied a small group (n=18) of children to redress this issue. The children were all undergoing cardiac […]
Induction of Anaesthesia for Children. Should We Recommend the Needle of the Mask?
In his editorial Professor Davidson comments on the Ramgolam et al. report findings. He mentions the well acknowledged pharmacological reasons for the advantages of IV induction; faster passage of the child through the excitement phases of anaesthesia and the avoidance of a pungent irritating gas. He questions how well the study group represents other paediatric […]
Inhalational versus Intravenous Induction of Anesthesia in Children with a High Risk of Perioperative Respiratory Adverse Events A Randomized Controlled Trial
The aim of this study was to examine the risk of adverse respiratory events with either intravenous induction (IV) with Propofol or inhalational induction with sevoflurane in children. The trial was performed at The Princess Margaret Hospital for Children in Perth between 2010 and 2013 and involved 300 children between 0.7 to eight years of […]
Intra-operative lidocaine in the prevention of vomiting after elective tonsillectomy in children: A randomised controlled trial
The authors performed a double-blinded randomised controlled trial comparing intravenous lignocaine to placebo in reducing post-operative vomiting after tonsillectomy. Children, ASA 1 and 2, aged between 2 and 12 years of age scheduled for tonsillectomy (with or without adenoidectomy) were included. Children with a history of intellectual impairment, obesity, diabetes mellitus, use of any psychoactive […]
Does intranasal dexmedetomidine provide adequate plasma concentrations for sedation in children: a pharmacokinetic study.
Intranasal dexmedetomidine (DMT) has been used for sedation in children around the world (including in our institution) for some years now – interestingly in the absence of any pharmacokinetic data. This paper from Cincinnati Children’s Hospital Medical Centre studied a small group (n=18) of children to redress this issue. The children were all undergoing cardiac […]
Comparison of target-controlled infusion and manual infusion for propofol anaesthesia in Children.
This prospective, randomised controlled clinical trial compared a Propofol TCI infusion regime (Paedfusor) with a manual infusion regime in a variety of surgical procedures. Propofol accumulates when used as an infusion, potentially prolonging recovery after long operations. This study intended to see if a current TCI regime, that adjusts for this potential accumulation by reducing […]
